Protein splicing of SufB is crucial for the functionality of the Mycobacterium tuberculosis SUF machinery.

نویسندگان

  • Gaëlle Huet
  • Jean-Philippe Castaing
  • Didier Fournier
  • Mamadou Daffé
  • Isabelle Saves
چکیده

The SufBCD complex is an essential component of the SUF machinery of [Fe-S] cluster biogenesis in many organisms. We show here that in Mycobacterium tuberculosis the formation of this complex is dependent on the protein splicing of SufB, suggesting that this process is a potential new target for antituberculous drugs.

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عنوان ژورنال:
  • Journal of bacteriology

دوره 188 9  شماره 

صفحات  -

تاریخ انتشار 2006